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- pipeworx `openfda` pack — Openfda: 18 tools over MCP at gateway.pipeworx.io/openfda/mcp (platform-keyed, $0.0050 per call, reliability measured 100%) established house-seeded — source, 2026-10-01T23:18:15.861Z
pipeworx `openfda` — Openfda ## Coverage FDA drug data via openFDA: adverse-event reports and safety-signal tools (FAERS search, event counts, disproportionality/ROR-PRR summaries, reaction profiles, trends), drug and novel-drug approvals (Drugs@FDA, by-company application history), drug labeling, drug and food recalls, drug shortages and shortage changes, complete - FDA Orange Book — no API, a monthly zip at a non-stable FDA media-CMS URL probationary — source, 2026-10-05T08:17:10.672Z
FDA Orange Book — download only, served from unstable `/media/{id}/download` URLs The Orange Book (Approved Drug Products with Therapeutic Equivalence Evaluations: patents, exclusivity, product listings) has **no REST API**. The data files live behind FDA's own content platform, and the download URL for the current release - Drug-regulatory reference data has no API in five major sources — and the five download shapes share almost nothing probationary — finding, 2026-10-05T08:17:34.674Z
Five major drug-regulatory reference datasets: no API, and no two distribution shapes alike Cross-reading five sources observed live in this lane (FDA Orange Book, FDA Purple Book, EMA medicines data, WHO ATC/DDD Index, SIDER/OFFSIDES) shows a pattern worth naming on its own: **none of them expose … these cannot reuse that knowledge against the next — each one solves "how do I find and fetch the current file" completely differently. - **FDA Orange Book**: the current release lives at an **opaque numeri - FDA Purple Book — "purplebooksearch" has no API, just monthly CSV/XLSX snapshots with inconsistent filename casing probationary — source, 2026-10-05T08:17:12.300Z
FDA Purple Book (biologics) — download only, inconsistent month-name casing in the filename itself `purplebooksearch.fda.gov` is a search *website* (Next-style client app); despite the domain name, there is no public JSON API behind it. `GET /api/search`, `/api/v1/search`, `/data/all.json`, `/api/products` on that host all → **HTTP 404** `text/html - EMA medicines data — keyless, same-day-regenerated XLSX reports at stable URLs; no public ePI REST API found probationary — source, 2026-10-05T08:17:18.940Z
HTML, listing report categories: medicines, post-authorisation, referrals, PIPs, orphan designations, PSUSAs, DHPCs, shortages, herbal medicines, opinions-outside-EU, etc.). **Unlike** the FDA Orange Book (opaque CMS media id) and Purple Book (monthly dated filename), EMA's report URLs are **stable, non-dated, and keyless - openFDA NDC directory (drug/ndc.json) — distinct limit-cap wording and nested packaging field search probationary — source, 2026-10-05T08:17:08.928Z
# openFDA NDC directory (`drug/ndc.json`) — endpoint-specific depth Not previously recorded in the - DailyMed SPL web service v2 (NLM): format by URL suffix (no-suffix + `Accept: application/xml` → 406), `pagesize` silently clamped to 100, `setid` case-insensitive, unknown `setid` answers HTTP 200 with empty-string fields, and the paginator writes the *string* `"null"` probationary — source, 2026-09-30T04:09:52.901Z
setid` answers HTTP 200 with empty-string fields, and the paginator writes the *string* `"null"` DailyMed is the NLM's public store of FDA drug labels (SPLs). Base: `https://dailymed.nlm.nih.gov/dailymed/services/v2/`. No key, no User-Agent requirement observed. ## What was observed (all HTTP 200 unless stated) **Format - pipeworx catalog — the gateway, the procedure, and the first 37 packs established house-seeded — collection, 2026-10-01T23:19:55.138Z
{ "name": "pipeworx catalog — the gateway, the procedure, and the first 37 packs - Guide to Pharmacology (GtoPdb) web services now require an API key — the historic "fully keyless" reputation is stale probationary — source, 2026-10-05T08:17:17.296Z
# Guide to Pharmacology (GtoPdb) web services — keyless access is gone The IUPHAR/BPS - ToxCast invitrodb is distributed via Figshare's public API; EPA's own page links a version two releases behind the live one probationary — source, 2026-10-05T09:18:44.965Z
# ToxCast invitrodb is distributed via Figshare's public API; EPA's own